Also known as juvenile diabetes, type 1 diabetes is an autoimmune disease primarily affecting children and young adults. In patients with type 1 diabetes, the body attacks itself by destroying insulin-producing cells in the pancreas that regulate glucose, or blood sugar.
Led by Rusung Tan, a Pathology professor in the UBC Faculty of Medicine and co-head of the Immunity in Health and Disease research cluster at CFRI, the research team has identified the increased presence of Th17 cells, a type of T cell discovered in 2005, in children newly diagnosed with type 1 diabetes.
"T cells are white blood cells and key members of the immune system that control infections," says Tan, who is also a member of the Department of Pathology & Laboratory Medicine at BC Children’s Hospital and a senior scholar of the Michael Smith Foundation for Health Research.
"In healthy individuals, Th17 cells provide a strong defence against bacteria and viruses by guiding the immune system to strongly attack infected targets within our bodies."
However, Th17 has been associated with other autoimmune diseases such as Crohn’s disease, which suggests they can play a harmful role. Treatments designed to block Th17 cells are in clinical trials for these diseases.
“The elevated levels of Th17 cells in type 1 diabetes patients suggest that these cells may also play a key role in the early development of this disease in young patients,” says Tan. “This discovery opens the door to new treatments for childhood diabetes that target Th17 cells.”
The findings are published in the current issue of the Journal of Immunology. The team consists of researchers from UBC, CFRI and the Vancouver Coastal Health Research Institute. At the time of the study, lead author Dr. Ashish Marwaha was a master’s student at UBC and CFRI. The study was supported by grants from the Canadian Institutes of Health Research and the Juvenile Diabetes Research Foundation.
Microscopic image of a pancreatic islet, where insulin-producing cells live. Figure 1 (above) shows the beginning of an infiltration by white blood cells, many of which may be Th17. Figure 2 (below) shows a later stage of the infiltration in which most of the insulin-producing cells have been destroyed.
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ReplyDeleteThank you for this useful information for Th17 cells. These cells have been identified as a unique subset of T-helper cells and constitute a subset of cells known as neutrophil regulatory T-cells....